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March 19, 2026ESMO Open0 citationsOpen Access

154eP Real-world effectiveness and resource utilization of first-line pembrolizumab in NSCLC: A retrospective observational study (MOSAICO study)

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AUAntonio UngaroMCM. CalcagnoTGTiziana Guarino

Key Points

  • The study aims to evaluate the real-world effectiveness and cost-effectiveness of first-line pembrolizumab in treating metastatic NSCLC.
  • Retrospective observational study design
  • Analysis of long-term patient outcomes
  • Utilization of quality-adjusted life-years (QALYs) and disability-adjusted life-years (DALYs)
  • Evaluation of incremental cost-effectiveness ratios (ICERs)
  • Improved survival rates associated with pembrolizumab therapy
  • Demonstrated durable benefits in patient quality of life
  • Highlighting the high upfront costs compared to long-term value metrics

Abstract

Anti–PD-1/PD-L1 therapy has reshaped the therapeutic paradigm of metastatic NSCLC, improving survival and enabling durable benefit. However, the high upfront expenditure associated with immunotherapy has increased the need to frame real-world effectiveness within long-term value metrics, including quality-adjusted life-years (QALYs), disability-adjusted life-years (DALYs) and incremental cost-effectiveness ratios (ICERs), to better capture downstream gains in quality and quantity of life.

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Cite This Study

Ungaro et al. (2026) studied this question.

synapsesocial.com/papers/69bb9313496e729e62980db7https://doi.org/10.1016/j.esmoop.2026.106461
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