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March 19, 2026Journal of ToxicologyOpen Access

Integrative Analysis of Phthalates and Organophosphates in PM 2 . 5 ‐Driven Postmenopausal Osteoporosis: A Triangulated Approach Combining Bibliometrics, Network Toxicology, and Molecular Docking

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Authors

CZChang ZhouJZJiaheng ZhangYGYanghongxu Guo

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Overview

Integrative analysis shows phthalates and organophosphates disrupt bone health in postmenopausal women, highlighting environmental impacts.

Key Points

  • To investigate the systemic mechanisms through which phthalates and organophosphates in PM2.5 may contribute to postmenopausal osteoporosis.
  • Conducted bibliometric analysis from 2013 to 2024 to track research trends
  • Applied network toxicology to identify common targets of PMOP-related compounds
  • Performed GO and KEGG enrichment analyses for biological insights
  • Constructed a protein-protein interaction network to find core targets
  • Executed molecular docking to assess binding affinities of key pollutants with target proteins.
  • Bibliometric analysis showed a lack of mechanistic studies on PAEs and OPEs in PMOP
  • Network toxicology identified 122 core targets linked to oxidative stress, inflammation, and apoptosis
  • PPI network identified BCL2 and ESR2 as critical proteins
  • Molecular docking revealed strong binding affinities of DEHP, MEHP, and TPHP with BCL2 and ESR2.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69bb9313496e729e62980e5ehttps://doi.org/10.1155/jt/4727798
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