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March 21, 2026BMC Medicine0 citationsOpen Access

Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules

YWYuanyuan WuDSDong SunZZZhiming Zhou

Key Points

  • To examine the relationship between relative leukocyte telomere length (rLTL) and lung cancer progression in individuals with pulmonary nodules.
  • Analyzed health check-up data from individuals with pulmonary nodules.
  • Measured relative leukocyte telomere length (rLTL) in participants.
  • Assessed lung cancer risk factors and progression outcomes.
  • Longer rLTL is associated with increased risk of lung cancer.
  • Findings suggest a paradoxical role of telomere biology in lung cancer development.
  • rLTL may be used as a biomarker for malignancy risk in surveillance.

Abstract

In this health check-up cohort of individuals with pulmonary nodules, longer rLTL was independently associated with increased lung cancer risk. Our findings highlight a potentially paradoxical role of telomere biology in lung carcinogenesis and suggest that rLTL may serve as a useful biomarker for malignancy risk stratification in nodule surveillance.

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69be34af6e48c4981c672cedhttps://doi.org/10.1186/s12916-026-04788-x
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