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This research aims to evaluate the effectiveness of a structured Mind-Body Intervention on anxiety and overall quality of life in patients with unresectable pleural mesothelioma.

March 21, 2026ESMO Open0 citationsOpen Access

338eP Immunotherapy with or without chemotherapy for first line treatment of unresectable pleural mesothelioma (PM): A systematic review and meta-analysis

GVGiuseppe Viscardi MBM. Brambilla PAPaolo Ambrosini

Puntos clave

This research aims to evaluate the effectiveness of a structured Mind-Body Intervention on anxiety and overall quality of life in patients with unresectable pleural mesothelioma.
Randomized 1:1 allocation into two groups: Mind-Body Intervention (MBI) and Best Supportive Care (BSC).
Conducted assessments at baseline, post-intervention (Week 8), and 3 months follow-up.
Used the Hospital Anxiety and Depression Scale (HADS) and EORTC QLQ-C30 for evaluations.
The MBI Group showed a significant reduction in HADS-Anxiety score, decreasing by 2.5 points compared to 0.4 points in the BSC Group.
38.3% of patients exhibited high psychological distress at baseline.
65% of patients in the MBI Group achieved clinically significant anxiety reduction versus 5% in BSC.
Improvements in Emotional Functioning scores were significant for the MBI Group.

Resumen

Background: Malignant Pleural Mesothelioma (MPM) is associated with severe psychological morbidity due to its aggressive prognosis and occupational etiology.The psychological distress experienced by patients with aggressive cancers, such as lung cancer, is notably high, with approximately 35% of patients exhibiting symptoms of anxiety or depression warranting clinical attention (HADS score 8).Integration of psychosocial support into routine care is lacking, underscoring a critical unmet need for improving patient-reported quality of life (QoL).Methods: A total of 60 newly diagnosed patients with unresectable MPM were randomized 1:1 into the MBI Group (n=30), receiving weekly sessions of mindfulness and guided imagery, or the BSC Group (n=30).Patients were assessed at baseline, post-intervention (Week 8), and at 3-month follow-up using the Hospital Anxiety and Depression Scale (HADS) and the EORTC QLQ-C30.The primary endpoint was the change in HADS-Anxiety score at Week 8.Results: At baseline, the mean HADS-Anxiety score for the entire cohort was 7.1 3.2, with 38.3% (n=23) of patients scoring 8 on either the anxiety or depression subscale, confirming a high psychological burden.At Week 8, the MBI Group demonstrated a mean reduction in HADS-Anxiety score of 2.5 points (from 7.2 at baseline to 4.7 post-intervention), compared to a reduction of only 0.4 points in the BSC Group (from 7.0 to 6.6).This difference was statistically significant (p < 0.001) and exceeded the minimal clinically important difference of 1.5 points.The proportion of patients with clinically significant anxiety (HADS-A 11) decreased by 65% in the MBI Group (from 20% to 7%), versus a 5% decrease in the BSC Group.Furthermore, the MBI Group reported a significant improvement in the Emotional Functioning domain of the QoL assessment (p = 0.012).No safety concerns or adverse events related to the MBI were reported. Conclusions:A structured, eight-week Mind-Body Intervention is a safe and highly effective non-pharmacological adjunct treatment for MPM patients.It resulted in a clinically and statistically significant reduction in anxiety & primary source of distress.

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