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March 21, 2026ACS Nano

Hierarchically Targeted Cu-Doped Carbon Dot/Kynurenic Acid@RM Platform for Restoring Mitochondrial Metabolism and Modulating Inflammation in Acute Pancreatitis

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Authors

XZX. J. ZhaoTWTing WangQZQi Zhou

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Overview

Nanotherapeutic RMCK improves mitochondrial function and reduces inflammation in acute pancreatitis, indicating a new treatment approach.

Key Points

  • The study aims to evaluate a novel nanotherapeutic for restoring mitochondrial metabolism and reducing inflammation in acute pancreatitis.
  • Developed hierarchically targeted Cu-CDs/Kyna@RM nanotherapeutics.
  • Administered RMCK systemically to an acute pancreatitis model.
  • Conducted in vitro experiments to assess acinar cell injury and mitochondrial function.
  • Utilized transcriptomics and immunohistochemistry for mechanistic analysis.
  • RMCK significantly improves survival rates in acute pancreatitis models.
  • Reduces serum amylase and lipase levels, indicating improved pancreatic function.
  • Alleviates pancreatic edema and necrosis, and prevents secondary lung injury.
  • In vitro results show reduced acinar cell injury and LDH release.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69be34d16e48c4981c672e8dhttps://doi.org/10.1021/acsnano.5c14940
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