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March 21, 2026Nature CommunicationsOpen Access

IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation

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Authors

CKCody KempenASAnkita SinghKBKeith A. Breau

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Overview

Experimental analysis reveals IL-17RA signaling aids Paneth cell regeneration in intestinal tissues post-injury, implying a new therapeutic target.

Key Points

  • To explore the role of IL-17RA signaling in Paneth cells for tissue regeneration after intestinal injury.
  • Utilized Paneth cell-specific IL-17RA knockout mice.
  • Conducted anti-IL-17A neutralizing studies.
  • Employed lineage tracer mice to track cellular changes.
  • Assessed the effects of ADAM17 overexpression in mutant mice.
  • IL-17RA signaling is essential for Paneth cells to acquire stem-like properties.
  • Reduced ADAM17 expression linked to regeneration defects in specific knockout mice.
  • Overexpressing ADAM17 rescues regeneration issues in IL-17RA knockout mice.
  • IL-17A enhances Nox1 expression, leading to increased ADAM17 activity.

Cite This Study

Kempen et al. (2026) studied this question.

synapsesocial.com/papers/69be34d16e48c4981c673045https://doi.org/10.1038/s41467-026-70479-z
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