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March 21, 2026Chemical and Pharmaceutical Bulletin0 citationsOpen Access

Asymmetric Conjugate Addition of Thiophene Derivative to Nitrostyrenes Using Thiourea Organocatalysts

TKTaro KodaHAHiroshi AkutsuMSMitsuaki Suzuki

Key Points

  • To explore the asymmetric α-regioselective conjugate addition of thiophene derivatives to nitrostyrenes using thiourea organocatalysts.
  • Utilized a tertiary amine-thiourea organocatalyst
  • Performed reactions with 2-thienylacetones and nitrostyrenes
  • Evaluated yields and stereoselectivities of α-addition products
  • Achieved high yields of α-addition products
  • Obtained excellent stereoselectivities
  • Demonstrated the feasibility of the reaction with nitroalkenes

Abstract

The asymmetric α-regioselective conjugate addition of 2-thienylacetones to nitrostyrenes was achieved using a tertiary amine-thiourea organocatalyst, affording the α-addition products in high yields with excellent stereoselectivities. This study provides the first demonstration of an asymmetric α-regioselective conjugate addition of 2-thienylacetones to nitroalkenes.

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Cite This Study

Koda et al. (2026) studied this question.

synapsesocial.com/papers/69be34f26e48c4981c673151https://doi.org/10.1248/cpb.c25-00802
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