PSA density was identified as an independent preoperative predictor of incidental prostate cancer following HoLEP, whereas older age, higher total PSA, and elevated PSA density were found to be clinically significant factors associated with clinically significant cases. In older patients with high PSA density, further evaluation for possible prostate cancer may be considered before HoLEP, particularly if the detection of clinically significant disease would alter the decision to proceed with surgery.
Özsoy et al. (2026) studied this question.
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