Stoichiometry Dependent Modifications in Synthetic Heme Peroxo Reactivity with Nitrosonium: A New Paradigm for Understanding Heme Mediated Nitration Chemistry

Key Points

• This research aims to explore how stoichiometry affects the reaction pathways of synthetic heme–peroxo complexes with nitrosonium.
• Conducted reactivity studies with synthetic heme–peroxo complexes
• Used varying stoichiometric amounts of nitrosonium (NO⁺)
• Analyzed the resulting reaction mechanisms and pathways
• Identified a new reaction pathway that differs from traditional nitric oxide dioxygenase (NOD) chemistry
• Demonstrated that excess NO⁺ leads to significant changes in reactivity
• Uncovered insights into heme-mediated nitration processes