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March 21, 2026BMJ OpenOpen Access

Reliability and validity of EuroQol-5 Dimensions-5 Levels in patients with haematologic malignancies: a cross-sectional study in China

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Authors

WQWei QinYCYa ChenYOYuyan Ouyang

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Overview

Cross-sectional study assesses EuroQol-5 Dimensions performance in haematologic malignancies, indicating its reliability in some groups.

Key Points

  • The aim is to evaluate the reliability and validity of the EuroQol-5 Dimensions instrument in patients with haematologic malignancies.
  • Conducted a cross-sectional observational study
  • Employed EuroQol-5 Dimensions and time trade-off to assess health-related quality of life
  • Included 158 patients with multiple myeloma, acute leukaemia, and lymphoma
  • Analyzed EQ-5D performance based on internal consistency, criterion validity, and structural validity
  • Total utility scores were highest in acute leukaemia (0.798), lower in lymphoma (0.755), and lowest in multiple myeloma (0.693)
  • EQ-5D utility values were consistently higher than TTO across all groups
  • EQ-5D showed excellent internal consistency (Cronbach’s α=0.899) and the strongest correlation with TTO in multiple myeloma patients (r=0.538, p<0.001)
  • Moderate validity in acute leukaemia (r=0.386, p=0.002) and poor validity in lymphoma (r=0.230, p=0.129)
  • Chronic kidney failure correlated with greater TTO–EQ-5D utility discrepancy in acute leukaemia patients

Cite This Study

Qin et al. (2026) studied this question.

synapsesocial.com/papers/69be35946e48c4981c673ec9https://doi.org/10.1136/bmjopen-2025-109028
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