Lactobacillus combination alleviates dextran sulfate sodium-induced colitis in Wuzhishan minipigs

Key Points

• The research aims to evaluate the effects of a Lactobacillus combination on colitis in minipigs.
• Induced colitis in Wuzhishan minipigs using dextran sulfate sodium.
• Administered a combination of Lactobacillus strains.
• Assessed oxidative stress, inflammation, gut barrier function, and microbiota composition.
• Lactobacillus combination significantly reduced markers of oxidative stress.
• Inflammation levels decreased after treatment.
• Improvement in gut barrier function was observed.
• The microbiota was positively modulated, accompanying an increase in SCFA levels.