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March 21, 2026Open Access

Genomic and spatial analysis of local recurrences following risk-adapted breast radiotherapy in the IMPORT trials

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Authors

CCCharlotte E. ColesSLSara Lightowlers

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Overview

Examines local recurrences in breast cancer post-radiotherapy, indicating implications for patient management.

Key Points

  • The main aim is to determine the relationship between local recurrences and new primary tumors after radiotherapy in breast cancer.
  • Assessed clonal relationships using paired samples from two radiotherapy trials.
  • Performed copy number profiling and targeted sequencing of DNA.
  • Analyzed spatial relationships through computational co-registration of imaging.
  • 61% of local recurrences were clonally related to the original tumor in high-risk patients.
  • Only 32% were related in low-risk patients.
  • Higher clonal recurrence rates were observed in patients diagnosed within 5 years of treatment.
  • Four out of 18 contralateral tumors in high-risk patients were genomically similar to index cancers.

Cite This Study

Coles et al. (2026) studied this question.

synapsesocial.com/papers/69be35f96e48c4981c6747cfhttps://doi.org/10.17863/cam.128482
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