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March 21, 2026VirusesOpen Access

The Gene Encoding the Antisense Protein ASP of HIV-1: Origin, Distribution and Maintenance

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Authors

MHMyriam Abla HoumeySSSara SadekCDCoralie F. Daussy

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Overview

Narrative review and analyses clarify ASP's origin and role in HIV-1 adaptation, suggesting evolutionary significance.

Key Points

  • The aim is to clarify the origin and maintenance of the ASP open reading frame in HIV-1.
  • Combined narrative review of HIV-1 literature and in silico analyses of sequences from the Los Alamos National Laboratory database.
  • Assessed the distribution and conservation of the ASP open reading frame across various HIV-1 groups and SIV lineages.
  • Evaluated length variability of the ASP ORF in pandemic HIV-1 group M and related SIVs.
  • Confirmed strong association between 'intact' ASP ORF and HIV-1 group M lineages.
  • Revealed rare antisense ORFs in specific SIVcpz and SIVgor strains.
  • Supported the theory that the asp gene contributed to HIV-1's adaptation and global spread.

Cite This Study

Houmey et al. (2026) studied this question.

synapsesocial.com/papers/69be36f76e48c4981c6763fehttps://doi.org/10.3390/v18030381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Antisense Protein ASP of HIV-1 Enhances Viral Entry in CD4+ T Cells2025
  2. 2Patterns of Diversity and Humoral Immunogenicity for HIV-1 Antisense Protein (ASP)2024 · 4 citations
  3. 3The Origins and Genetic Diversity of HIV-1: Evolutionary Insights and Global Health Perspectives2025
  4. 4HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels2025
  5. 5Possible acquisition and molecular evolution of<i>vpu</i>genes inferred from comprehensive sequence analysis of human and simian immunodeficiency viruses2024