The nature of trehalose–protein interactions in aqueous solutions revealed by neutron scattering

Key Points

• This research investigates the interactions between trehalose and proteins in water, focusing on how trehalose stabilizes proteins.
• Utilized neutron scattering to observe protein and trehalose interactions in aqueous solutions.
• Analyzed the structural changes in proteins when exposed to trehalose under varying conditions.
• Trehalose effectively interacts with proteins, aiding in their stabilization during dehydration.
• The findings suggest that exclusion of trehalose from the protein surface plays a crucial role in stabilization.

Abstract