Bioactive peptide fractions from Vigna unguiculata : Inhibition kinetics, gastrointestinal stability, cytotoxicity assessment, and amino acid profile as compositional features associated with antihypertensive activity

Key Points

• The aim is to evaluate the antihypertensive potential of bioactive peptide fractions from Vigna unguiculata.
• Analyzed peptide fractions for ACE-I inhibition
• Assessed gastrointestinal stability under digestive conditions
• Evaluated cytotoxicity levels of the peptides
• Characterized amino acid profile of the fractions
• Peptide fractions showed non-competitive inhibition of ACE-I
• Demonstrated high stability during digestion
• Exhibited low levels of cytotoxicity
• Identified relevant amino acids associated with antihypertensive effects

Abstract