An efficient synthesis of organothiophosphates from sodium sulfinates and chlorophosphines (R2PCl) is described. The mechanism involves a P(III) to P(V) rearrangement of S-O-PR2 species leading to S-P bond formation, which may be catalyzed by chloride ions generated in situ. Notably, the chlorophosphines play dual roles as both the phosphorus source and the reductant. The synthesis features mild conditions, short time, a broad substrate scope, and the use of a stable and odorless sulfur source.
Li et al. (Wed,) studied this question.
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