Controversies in neuroendocrine neoplasms: An European Neuroendocrine Tumor Society position statement on the role of surgery of the primary tumour in metastatic small intestinal and pancreatic neuroendocrine tumours
Position statement evaluates surgery's impact on metastatic small intestinal and pancreatic neuroendocrine tumours, suggesting selective use for improved outcomes.
Key Points
This position statement aims to clarify the role of primary tumour resection in metastatic small intestinal and pancreatic neuroendocrine tumours based on expert consensus.
Reviewed current knowledge and debates on primary tumour resection (PTR).
Discussed patient selection, potential benefits, and integration with systemic therapies.
Evaluated risks associated with major surgical interventions, including quality of life implications.
Indicates that PTR may improve survival in selected patients with specific disease presentations.
Highlights the lack of prospective studies and the presence of selection bias in current evidence.
Calls for further research into molecular biomarkers and patient-reported outcomes.