Enantioselective reductive cyclization of alkynals via cobalt catalysis

Key Points

• The aim is to develop a novel cobalt-catalyzed method for the intramolecular reductive cyclization of alkynals to generate chiral products.
• Utilized cobalt as the catalyst for the intramolecular reaction
• Investigated the substrate scope of alkynes and aldehydes
• Analyzed reaction conditions to optimize enantioselectivity
• Successfully achieved high enantioselectivity in the cyclization process
• Generated a range of chiral allylic alcohol derivatives
• Demonstrated the effectiveness of cobalt catalysts in asymmetric synthesis