Application of VVI layered strain technology to analyze changes in left ventricular myocardial motion in patients with uremia

Objective Velocity vector imaging (VVI) stratified strain analysis was used to assess circumferential strain across myocardial layers in uremic patients using a 16-segment left ventricular model. Methods Data were accessed for research purposes from 1/5/2025–1/6/2025. Sixty hemodialysis patients were divided into left ventricular hypertrophy (LVH, n = 30) and normal LV conformation (LVN, n = 30) groups based on LV mass index, alongside 27 healthy controls (CON). Clinical and echocardiographic data were analyzed, with VVI quantifying systolic circumferential strain (CS) in endocardial (Endo), mid-myocardial (Myo), and epicardial (Epi) layers. Results The LVH and LVN groups exhibited significant differences compared to the CON group in SBP, Hb, BUN, Scr, eGFR, and hsCRP levels ( P 0.05). Basal and mid-segment global strain were impaired in LVH/LVN ( P 0.05). Conclusions The VVI layered strain technique is a precise and sensitive tool for evaluating LV myocardial motion in uremic patients.