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March 22, 2026Proceedings of the National Academy of Sciences

Identification of somatostatin + inhibitory engrams for extinction in the basolateral amygdala

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Authors

XZXu ZhangZLZhaohui LanYHYan Huang

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Overview

Research demonstrates neural mechanisms involved in fear extinction in the basolateral amygdala, suggesting targets for PTSD treatment.

Key Points

  • The aim is to investigate the mechanisms controlling fear extinction and memory in the basolateral amygdala.
  • Developed a chemogenetic strategy for tagging GABAergic interneurons.
  • Investigated the role of extinction-tagged and acquisition-tagged BLA neurons in fear memory.
  • Utilized activity-dependent manipulation for better sensitivity and specificity.
  • Silencing extinction-tagged BLA neurons resulted in fear memory relapse.
  • Silencing GABAergic neurons restored fear expression after extinction.
  • Establishment of specific inhibitory GABAergic engrams during fear extinction was confirmed.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69bf3955c7b3c90b18b43f7dhttps://doi.org/10.1073/pnas.2511528123
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Corticotropin-releasing factor and somatostatin neurons in the central amygdala mediate dynamic defensive behaviors during fear extinction2026
  2. 2Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus2026
  3. 3Infralimbic projections to the basal forebrain mediate extinction learning2024 · 1 citations
  4. 4Inhibitory fear memory engram in the mouse central lateral amygdala2024 · 2 citations
  5. 5Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.2024