Unraveling the role of boron microdistribution in BNCT dosimetry of glioblastoma multiforme: combined theoretical and experimental insights

Key Points

• The research aims to understand how boron distribution affects dosimetry in BNCT for glioblastoma multiforme.
• Developed a Microdosimetric Model based on experimental microdosimetric corrections.
• Conducted subcellular-scale modeling to analyze boron microdistribution effects.
• Integrated theoretical frameworks with experimental data to validate findings.
• The new model significantly improves the accuracy of BNCT dosimetry.
• Personalization of treatment planning is enhanced through detailed microdosimetric insights.
• Findings underscore the importance of boron distribution at the cellular level.

Abstract