Protective Effect of Boswellia carterii and Gum Arabic (Senegalia senegal) on Induced Arthritic in Male Rats

The study aims to use natural substances like Senegalia senegal and Boswellia carterii to treat rheumatoid arthritis, a painful disease affecting joints and making movement difficult, , The two plants were used to treat the symptoms of induced arthritis in male rats by using the complete freund's adjuvant method. A group of thirty adult male rats was used in this study, divided into six groups, with five rats for each group. The 1st group was the negative control (without arthritis induced and without treatment); the 2nd group is the positive control group (with arthritis induced and without any treatment); the third group (arthritis induced and treated with 250 mg/kg B.W Boswellia carterii); the fourth group (arthritis induced and treated with400 mg/kg B.W. Senegalia senegal); the fifth group (arthritis induced and treated with Boswellia carterii and Senegalia senegal) and the 6th arthritis induced and treated with 0.75 mg/kg of drug methotrexate, The treated and affected joints underwent histological studies after six weeks of experiments, revealing significant changes in the affected joint tissue. The study found that arthritic animals intubated with Senegalia senegal showed normal joint cavity and epiphyseal ends. while those intubated with Boswellia carterii showed thinning of articular cartilage and synovial membrane and clear chondrocytes. Results of Senegalia senegal and Boswellia carterii showed thinning of articular cartilaginous and normal cavity with normal epiphyseal ends and hyperplasia of fibroblasts in the synovial membrane. In animals receiving methotrexate, they showed normal articular cartilaginous surfaces, narrowing joint cavities, and synovitis.