A comparison of differential DNA methylation analysis methods for continuous outcomes: implications for epigenetic studies

Key Points

• This analysis aims to compare different methods for DNA methylation analysis on continuous outcomes.
• Compared various differential methylation analysis methods
• Evaluated impact on CpG-level reproducibility
• Assessed within chromosome co-location
• Analyzed predictive accuracy of methods
• Choice of method affects CpG-level reproducibility
• Influences within chromosome co-location
• Limma method shows strong reproducibility and predictive value

Abstract