Rabdosin B suppresses proliferation of nonsmall cell lung cancer by regulating the SRC/PI3K/AKT signaling pathway

Key Points

• The research aims to investigate how Rabdosin B affects the proliferation of nonsmall cell lung cancer by targeting specific molecular pathways.
• Inhibition of NSCLC progression was tested using Rabdosin B.
• SRC was directly targeted to study its role in the PA3K/AKT pathway.
• The interaction between Rabdosin B and CDDP was analyzed.
• Rabdosin B significantly inhibits the proliferation of nonsmall cell lung cancer cells.
• Targeting SRC leads to inactivation of the PI3K/AKT signaling pathway.
• The combination with CDDP enhances the sensitivity of cancer cells to treatment.

Abstract