Intravenous non-specific immunoglobulins as adjunctive therapy for invasive Streptococcus pyogenes infection: an eleven-year retrospective study

Key Points

• This study aims to evaluate the effectiveness of intravenous immunoglobulins (IVIG) as adjunctive therapy for invasive Streptococcus pyogenes infections.
• Conducted a retrospective analysis over eleven years
• Examined the impact of high-dose IVIG with targeted antibiotics
• Assessed patient outcomes related to mortality rates
• Mortality rates were similar to or lower than previously reported
• Initial disease severity, hepatic dysfunction, and CRRT need increased mortality risk
• IVIG showed a favorable safety profile during treatment

Abstract