Comparing The Levels of Some Biochemical Markers in Rheumatoid Arthritis Patients With and Without Depression

One of the most common comorbidities of rheumatoid arthritis is depression, which is an independent mood disorder. This study aims to examine the blood levels of some biochemical markers in rheumatoid arthritis patients with and without depression compared to healthy group. This study included three groups: rheumatoid arthritis patients with depression, rheumatoid arthritis patients without depression, and a healthy group. The results showed that patients groups had significantly (P ≤ 0.05) higher activity of acetylcholine esterase and ceruloplasmine, carbonyl, ischemic modified albumin (IMA), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α ), Haptoglobin, and Cupper, and significantly (P ≤ 0.05) lower levels of total protein, albumin, globulin, thiol, iron, and zinc than control group. Free amino was significantly (P ≤ 0.05) lower in patients with depression group compared to the control and significantly (P ≤ 0.05) increases in patients with Rheumatoid arthritis without depression compared to control. Serotonin was significantly (P ≤ 0.05) lower in patients with depression group compared to the control and significantly (P ≤ 0.05) increases in patients with Rheumatoid arthritis, the study suggests that the presence of depression in Rheumatoid arthritis patients is associated with additional biochemical changes that may reflect more severe or complex pathophysiological interactions. The lower levels of serotonin and free amino in Rheumatoid arthritis patients with depression indicate a potential link between mood disturbances and biochemical imbalances.