Aquaporin 1 promotes proliferation and migration of tumor by up-regulating claudin-1 expression in colon cancer

Key Points

• The research aims to investigate the role of aquaporin 1 in enhancing colon cancer cell proliferation and migration through claudin-1 expression.
• Analyzed aquaporin 1 expression levels in colon cancer samples
• Evaluated the correlation between aquaporin 1 and claudin-1
• Performed cellular assays to assess proliferation and migration rates
• AQP1 levels were higher in colon cancer tissues compared to normal tissues
• Increased AQP1 expression was associated with elevated claudin-1 levels
• Cell assays indicated that higher AQP1 led to increased cell proliferation and migration.

Abstract