Zinc-Manganese Sulfide Nanoplatform for Tumor-Microenvironment-Responsive Chemodynamic/Gas Therapy and Immunomodulation

Key Points

• The goal is to enhance the effectiveness of chemodynamic therapy in cancer treatment using a zinc-manganese sulfide nanoplatform.
• Developed a nanoplatform made of zinc-manganese sulfide.
• Assessed the release of hydrogen peroxide in the tumor microenvironment.
• Evaluated the immunomodulatory effects of the nanoplatform.
• Demonstrated improved hydrogen peroxide generation in solid tumors.
• Increased cell death in tumor models compared to standard chemodynamic therapy.
• Enhanced immune response against tumor cells.

Abstract