The Correlation of Total IGE, And Complete Blood Count in the Sera of Allergic Rhinitis Patients in Babylon Province, Iraq

ABSTRACT Background: Allergic rhinitis (AR) is a common condition that affects the quality of life for sufferers all over the world. AR is a chronic immunoglobulin E-mediated inflammatory condition caused by aeroallergens. Objectives: The purpose of this research is to investigate the correlation between the clinical severity of allergic rhinitis patients and the levels of total IgE, complete blood count, disease duration, and disease onset among patients. Methods: In this case-control study, 45 individuals with allergic rhinitis and 45 seemingly healthy controls of both sexes were randomly selected. Both the patient and control groups provided blood samples. To use the ELISA method to estimate the amount of total IgE, the complete blood count (CBC) test was performed automatically. Results: The study found a statistically significant increase (P < 0.001) in total IgE levels in allergic rhinitis serum compared to the control group. The linear regression analysis found a significant positive correlation between IgE and disease onset (p < 0.002). There were significant differences between WBC and lymphocytes (p < 0.02), neutrophils (p < 0.000), and eosinophils with red blood cells (p < 0.000). There is a significant negative connection between disease duration and onset (p < 0.000). Conclusion The findings showed that, in comparison to the control group, patients with allergic rhinitis had noticeably higher levels of inflammatory markers. High levels of eosinophils and IgE were indicated of allergic rhinitis, an inflammation of the airways. These linked them to the clinical severity of allergic rhinitis.