Esketamine nasal spray for treatment-resistant depression: A retrospective multicenter real-world cohort study on effectiveness and suicidal outcomes

Puntos clave

• This research aims to evaluate the effectiveness of esketamine nasal spray in reducing depressive symptoms and improving functioning in patients with treatment-resistant depression.
• Conducted a retrospective multicenter cohort study
• Assessed the progressive improvement of depressive symptoms
• Evaluated the impact during the optimization phase
• Observed significant reductions in depressive symptoms over time
• Improvements in functioning continued beyond the initial treatment phase
• Indicated positive effects on suicidal outcomes