Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus

Puntos clave

• The research aims to develop a targeted nucleic acid delivery system to combat multidrug-resistant Staphylococcus aureus infections.
• Utilized a tetrahedral framework nucleic acid platform for drug delivery
• Incorporated aptamers to target specific bacterial strains
• Evaluated antimicrobial efficacy against biofilm-producing bacteria
• Assessed immunomodulatory effects in skin infection models.
• Demonstrated effective delivery of emodin, an antimicrobial agent
• Significantly disrupted biofilm formation associated with bacterial infections
• Showed improved anti-inflammatory response in host tissues