What question did this study set out to answer?

The study aims to evaluate oolong tea-derived manganese nanoparticles as an alternative oral contrast agent for MRCP imaging, focusing on image quality and safety.

March 24, 2026Open Access

Oolong tea-derived manganese nanoparticles as an alternative oral negative contrast agent for MRCP imaging

Puntos clave

The study aims to evaluate oolong tea-derived manganese nanoparticles as an alternative oral contrast agent for MRCP imaging, focusing on image quality and safety.
True experimental design with pre-test and post-test control group setup.
Thirty healthy volunteers divided into three groups: Mn-NPs from oolong tea, manganese from oolong tea, and standard manganese chloride.
Assessment of signal-to-noise and contrast-to-noise ratios, along with blood levels of IL-1β and TNF-α post-contrast administration.
Mn-NPs from oolong tea decreased signal strength in gastric (3.40%) and duodenal (1.60%) regions.
Increased signal blockage was noted in several ducts including common hepatic (13.80%) and pancreatic ducts (3.10%).
IL-1β and TNF-α levels remained stable, indicating no neurotoxic effects.
Oolong tea-derived Mn-NPs showed superior imaging performance and enhanced safety profile due to anti-inflammatory components.

Resumen

Background/Aim: Conventional natural manganese contrast agent for magnetic resonance cholangiopancreatography (MRCP) have produced suboptimal visualisation of the gastric, duodenum and biliary system. While various studies have explored manganese-based media, limited research has focused on manganese nanoparticles (Mn-NPs). This study investigated oolong tea-derived Mn-NPs as a potential alternative oral contrast agent for MRCP imaging, aiming to enhance image clarity while minimising neurotoxic effects in healthy volunteers.Methods: A true experimental approach with a pre-test and post-test control group setup was employed, involving thirty healthy volunteers divided into three groups: (K1) Mn-NPs derived from oolong tea, (K2) manganese extracted from oolong tea and (K3) standard manganese chloride. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and blood levels of IL-1β and TNF-α were assessed preand post-contrast administration for efficacy and neurotoxicity.Results: The extracted Mn-NPs of oolong tea decreased signal strength in the stomach (3.40 %) and the duodenum (1.60 %), while increasing signal blockage in the gallbladder (0.80 %), cystic duct (4.40 %), common hepatic duct (13.80 %), intrahepatic duct (4.10 %), common bile duct (4.10 %) and pancreatic duct (3.10 %). These results outperformed those of standard contrast agent and manganese sourced from oolong tea. Interleukin 1 beta (IL -1β) (3.24 pg/mL) and tumour necrosis factor Alpha (TNF-α) (6.9 pg/mL) levels showed no neurotoxic effects. Mn-NPs from oolong tea showed superior imaging performance. This is due to their long residence time and stronger magnetic properties. The anti-inflammatory compounds in oolong tea likely contributed to the stable cytokine levels observed, indicating a good safety profile. In addition, integration with the FIESTA MRI suite further enhances image contrast.Conclusion: Mn-NPs prepared from oolong tea can be used instead of traditional contrast agent in MRCP examinations. They provide better image quality and do not harm the brain.

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