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March 25, 2026Clinical and Translational Gastroenterology0 citationsOpen Access

3D-Printed vs Commercial Distal Caps for ESD: Multicenter Randomized Ex Vivo Noninferiority Trial (ENDOPRINT Trial)

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KJKral JanDRDaryl RamaiJSJakub Svet

Key Result

3D-printed distal caps are as efficient and safe as commercial caps during ESD, while providing superior visibility, scope control, and tissue traction.

Key Points

  • This trial aims to compare the efficiency and safety of 3D-printed distal caps against commercial versions during endoscopic procedures.
  • Conducted as a multicenter randomized trial
  • Compared 3D-printed distal caps with commercial caps
  • Evaluated efficiency, safety, visibility, scope control, and tissue traction
  • 3D-printed distal caps were found to be as efficient as commercial caps
  • Provided better visibility and scope control
  • Lower material costs indicated for 3D-printed options

Structured PICO

Does a 3D-printed distal cap provide noninferior efficiency and safety compared to a commercial cap during ex vivo ESD?

P
Population
Ex vivo models for Endoscopic Submucosal Dissection (ESD)
I
Intervention
3D-printed distal cap
C
Comparator
Commercial distal cap
O
Outcome
Efficiency and safety during ESDsurrogate

Customizable 3D-printed distal caps are a safe, efficient, and potentially cost-effective alternative to commercial caps for ESD training and practice, offering superior scope control and visibility in ex vivo models.

Limitations

  • Ex vivo design requiring further in vivo validation
  • Lack of formal cost-effectiveness studies

Abstract

The ENDOPRINT trial demonstrated that a 3D-printed distal cap is as efficient and safe as a commercial cap during ESD, while providing superior visibility, scope control, and tissue traction. These results support the potential of customizable 3D-printed accessories with substantially lower per-unit material costs compared to commercial devices for clinical practice and training, warranting further in vivo validation and formal cost-effectiveness studies.

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Cite This Study

Jan et al. (2026) studied this question. 3D-printed distal caps are as efficient and safe as commercial caps during ESD, while providing superior visibility, scope control, and tissue traction.

synapsesocial.com/papers/69c37b81b34aaaeb1a67e0c4https://doi.org/10.14309/ctg.0000000000001022
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