What is the clinical evidence from this study?

Study design: Review. Population: Coronary artery disease requiring percutaneous coronary intervention. Intervention: Precision percutaneous coronary intervention vs. Traditional percutaneous coronary intervention.

What question did this study set out to answer?

This research focuses on improving the effectiveness and safety of percutaneous coronary interventions through precision strategies.

March 25, 2026Open Access

Precision percutaneous coronary intervention

Key Result

Precision-based percutaneous coronary intervention integrates individualized pre-, intra-, and post-procedural strategies, including intravascular imaging and physiology, to optimize clinical outcomes and minimize complications.

Key Points

This research focuses on improving the effectiveness and safety of percutaneous coronary interventions through precision strategies.
Integrated strategies applied during pre-, intra-, and post-procedural phases.
Evaluation of emerging evidence on the effectiveness of precision approaches in PCI.
Examination of artificial intelligence and pharmacogenomics in enhancing treatment personalization.
Precision strategies significantly reduce adverse events during PCI.
Improved procedural efficiency noted with the application of contemporary techniques.
AI and pharmacogenomics show potential for future personalized interventions, although still developing.

PICO

Population

Coronary artery disease requiring percutaneous coronary intervention

Intervention / Comparator

Precision percutaneous coronary intervention vs Traditional percutaneous coronary intervention

Limitations

Artificial intelligence and pharmacogenomics applications in PCI remain largely investigational and in early stages of development.
Lack of head-to-head randomized data for various calcium modification techniques.
Current integration strategies for discordant physiologic indices and plaque morphology remain variable.

Abstract

Abstract Precision-based percutaneous coronary intervention (PCI) integrates contemporary strategies across the pre-, intra-, and post-procedural phases to improve outcomes and minimize complications. Emerging evidence underscores the value of these strategies in reducing adverse events and improving procedural efficiency. While artificial intelligence and pharmacogenomics hold long-term promise for enhancing personalization, their clinical utility in PCI remains in the early stages of development.

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Discussion

Authors

Terrance M. Wilson

Uzair Munaf

Nafhat Shaikh

Actions

Institutions

Yale University

University of California, San Francisco

New York University

References and Citations

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Discussion

Cite this study

Wilson et al. (Mon,) conducted a review in Coronary artery disease requiring percutaneous coronary intervention. Precision percutaneous coronary intervention vs. Traditional percutaneous coronary intervention was evaluated. Precision-based percutaneous coronary intervention integrates individualized pre-, intra-, and post-procedural strategies, including intravascular imaging and physiology, to optimize clinical outcomes and minimize complications.

www.synapsesocial.com/papers/69c37bc2b34aaaeb1a67e6ff — DOI: https://doi.org/10.1038/s44325-026-00111-y

Precision percutaneous coronary intervention

Key Result

Key Points

PICO

Limitations

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study