Lingguizhugan Decoction Alleviates Lung Inflammatory in Obstructive Sleep Apnea by Modulating ROS and HIF‐1α Signaling Pathway Based on UHPLC–MS, Network Pharmacology, Transcriptomics, and Experimental Verification

Key Points

• Evaluate the effects of Lingguizhugan Decoction (LGZG) on lung inflammation in obstructive sleep apnea.
• Conducted chronic intermittent hypoxia (CIH) experiments in mice.
• Analyzed lung inflammation and immune response markers like IL-6.
• Used UHPLC–MS, network pharmacology, and transcriptomics for comprehensive analysis.
• LGZG alleviates CIH-induced pulmonary inflammation and neutrophil infiltration.
• Significant reduction in IL-6 secretion observed.
• Inhibition of reactive oxygen species (ROS) and HIF-1α signaling pathway noted.

Abstract