Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1 ‐mediated P53 ubiquitination

Key Points

• Investigate the role of Gorab deficiency in skin aging and its effect on P53 ubiquitination.
• Examined Gorab mutations in skin dermis samples
• Analyzed P53 accumulation levels
• Assessed ECM expression changes through epigenetic mechanisms
• Gorab mutations led to increased P53 levels in the dermis
• Disruption of ECM expression was observed
• Findings indicate a clear link between Gorab deficiency and accelerated skin aging

Abstract