Recent structural modification in halogenated flavonoids: a review

Flavonoids are secondary metabolites found in a wide variety of plants. They are widely used in food, medicine and other fields because of their good anti-inflammatory, anti-tumor and anti-oxidation activities. Literature research has revealed that flavonoids with halogenation modification exhibit an elevated level of biological activity, implying great potential for the further development and application of these kinds of compounds. This review summarises the latest progress in halogenation modification on natural flavonoids and their biological activity, aiming to provides reference for the development of halogenated flavonoid drugs.