Does left atrial appendage closure prevent death, stroke, or systemic embolism and reduce bleeding compared to oral anticoagulation in patients who underwent catheter-based atrial fibrillation ablation?
Patients who underwent catheter-based atrial fibrillation ablation
Left atrial appendage closure
Oral anticoagulation
Composite of death from any cause, stroke, or systemic embolism at 36 monthscomposite
In patients undergoing atrial fibrillation ablation, left atrial appendage closure is a viable alternative to oral anticoagulation, offering noninferior efficacy for stroke prevention and reduced bleeding risk at 3 years.
Among patients who underwent catheter-based atrial fibrillation ablation, left atrial appendage closure was associated with a lower risk of non-procedure-related major or clinically relevant nonmajor bleeding than oral anticoagulation and was noninferior to oral anticoagulation with respect to a composite of death from any cause, stroke, or systemic embolism at 36 months. (Funded by Boston Scientific; OPTION ClinicalTrials.gov number, NCT03795298.).
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Oussama Wazni
Walid I. Saliba
Devi G. Nair
New England Journal of Medicine
Emory University
Vanderbilt University
Cleveland Clinic
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Wazni et al. (Sat,) studied this question.
www.synapsesocial.com/papers/69c44441d52986ef1a828f00 — DOI: https://doi.org/10.1056/nejmoa2408308
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