Does the Hemoglobin A1c-systolic blood pressure index (HSI) predict incident cardiovascular disease better than HbA1c or SBP alone in prospective cohorts?
The Hemoglobin A1c-systolic blood pressure index (HSI) is a pragmatic, integrated tool that predicts incident cardiovascular disease better than either metric alone.
HSI, a simple composite of HbA1c and SBP, was consistently associated with incident CVD across three international cohorts. Its predictive ability exceeded that of HbA1c or SBP alone, highlighting it as a pragmatic tool for integrated cardiometabolic risk assessment. The findings warrant further clinical validation.
Zhang et al. (2026) studied this question.