This research aims to understand how the shape of nanocarriers and their lipid composition affect PEG-lipid shedding and their distribution in the body.
Analyzed different nanocarrier shapes and lipid compositions.
Measured PEG-lipid shedding rates in various conditions.
Assessed biodistribution in appropriate biological models.
Identified specific morphologies that enhance PEG-lipid retention.
Demonstrated varied biodistribution patterns based on lipid chemistry.
Highlighted the potential for design optimization in drug delivery systems.
Abstract
PEG-lipid shedding and biodistribution are shaped by nanocarrier morphology and lipid chemistry