Discovery of artemargyins A-E: rare 9'-nor-dibenzylbutane lignans and a lignan-coumarin hybrid with antihepatic fibrosis activities from Artemisia argyi var. gracilis

Key Points

• This research aims to isolate and characterize novel lignans from Artemisia argyi var. gracilis and evaluate their antihepatic fibrosis properties.
• Isolated artemargyins A-E and known compounds from plant material
• Utilized comprehensive spectroscopic techniques for structural elucidation
• Employed theoretical ECD calculations for configuration determination
• Five new lignans (artemargyins A-E) were successfully isolated
• Presence of antihepatic fibrosis activities was confirmed
• Structures were elucidated using advanced spectroscopic methods

Abstract