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March 26, 2026Helicobacter0 citationsOpen Access

The Association of a Positive Fecal Immunochemical Test With the Risk of Gastroesophageal Cancer: An Age‐Sex‐ H. Pylori Exposure Matched Cohort Study and Cost‐Effectiveness Analysis

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ZLZOHAR LEVINANaim Abu‐FrehaDBDoron Boltin

Key Points

  • The study aims to evaluate the risk of gastroesophageal cancer in individuals with a positive fecal immunochemical test.
  • Conducted a matched-cohort study comparing individuals with positive FIT and established high-risk groups.
  • Assessed the association of FIT results with gastroesophageal cancer incidence.
  • Performed a cost-effectiveness analysis for interventions using a one-time EGD alongside colonoscopy.
  • Individuals with a positive FIT exhibit an increased risk of gastroesophageal cancer.
  • The combination of EGD and colonoscopy is suggested as a cost-effective strategy for managing FIT-positive individuals.

Abstract

This matched-cohort study suggests that individuals with a positive FIT may have an increased risk of GEC, comparable to that of established high-risk populations. Adding a one-time EGD to colonoscopy for FIT-positive individuals may be a cost-effective approach for healthcare systems that can accommodate such interventions.

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Cite This Study

LEVI et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde448918557https://doi.org/10.1111/hel.70120
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