Vasopressor-induced digital ischemia is an uncommon but severe complication of life-preserving therapy in critically ill patients, arising from profound peripheral vasoconstriction that can progress from reversible hypoperfusion to irreversible necrosis and amputation. This review synthesizes current evidence on epidemiology, mechanisms of injury, early recognition, and management strategies relevant to the hand surgeon. Early ischemic changes—digital coolness, discoloration, and delayed capillary refill—may respond to timely interventions, such as active warming, topical nitrates, botulinum toxin A, and regional anesthesia-mediated sympatholysis. However, careful assessment for alternative etiologies, such as line extravasation or arterial thrombosis, remains essential. Once necrosis is established, treatment prioritizes digit protection, infection surveillance, expectant demarcation, and amputation at the most distal viable level, with periarterial surgical sympathectomy serving as a potential adjunct in selected cases. Given the paucity of high-level evidence, future efforts should focus on multicenter data collection, standardized monitoring, and translational investigations aimed at improving limb salvage while preserving hemodynamic stability.
Smith et al. (2026) studied this question.