This research demonstrates a free-radical reaction that enables β-C-H functionalization in aliphatic carbonyl compounds, suggesting a novel synthetic strategy.
Key Points
The study aims to develop a method for β-C-H functionalization of aliphatic ketones, esters, and acids using quinones.
Introduced a free-radical-promoted coupling reaction
Targeted simple aliphatic ketones, esters, and acids
Avoided the use of exogenous directing groups and transition metals
Achieved site-selective β-C-H functionalization
Facilitated the formation of β-C-C bonds
Provided a new strategy for the selective alkylation of quinones