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Synapse
March 26, 2026AIDS1 citations

Estimating the degree of cardiovascular disease risk under-prediction in people living with HIV by existing risk models: an updated meta-analysis

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MKMichael KwokHDHari DandapaniNINouran Ibrahim

Key Points

  • The research aims to evaluate how existing cardiovascular disease risk models underpredict risk in individuals living with HIV.
  • Conducted a meta-analysis of existing cardiovascular disease risk models
  • Assessed calibration of PCE-10 and FRS-10 scores
  • Evaluated risk prediction specifically for people living with HIV
  • Confirmed underprediction of cardiovascular disease risk in people living with HIV
  • Notably, lower expected risk individuals were significantly affected
  • PCE-10 and FRS-10 demonstrated superior calibration compared to other models

Abstract

Extant risk scores underpredict CVD risk in PLHIV, especially for individuals with lower expected risk, suggesting a need for implementation of HIV-specific calibration factors in this population. PCE-10 and FRS-10 showed better calibration.

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Cite This Study

Kwok et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccd6fdc3bde448918748https://doi.org/10.1097/qad.0000000000004492
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