Electroreductive Cross-Electrophile Coupling of Polyfluoroarenes for the Synthesis of Polyfluoroarylmethanes and Polyfluorinated Biaryls

Puntos clave

• The study aims to develop a method for functionalizing polyfluoroarenes, addressing challenges related to C–F bond inertness.
• Utilized electroreductive techniques for cross-electrophile coupling.
• Applied reaction conditions suitable for incorporating polyfluoro groups.
• Analyzed various reaction parameters to optimize yields.
• Successfully synthesized polyfluoroarylmethanes from polyfluoroarenes.
• Demonstrated that the method works under milder conditions compared to traditional approaches.
• Achieved high yields of polyfluorinated biaryls, indicating a promising avenue for further research.