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Synapse
March 26, 2026RespirologyOpen Access

OSA Endotyping as Targets for Treatment. How Far Have We Come?

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Authors

WMW.T. McNicholasSBSara Op de BeeckPTPasquale Tondo

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Overview

Endotyping reveals alternative therapies for obstructive sleep apnoea, suggesting a shift from CPAP for less severe cases.

Key Points

  • The aim is to explore how endotyping in obstructive sleep apnoea can inform treatment options beyond CPAP.
  • Reviewed endotypes of obstructive sleep apnoea and their relevance to treatment options.
  • Examined current non-CPAP therapies including oral appliances and pharmacotherapy.
  • Analyzed reports on identifying endotypic factors that influence treatment decisions.
  • Continued dominance of CPAP for moderate and severe cases of obstructive sleep apnoea.
  • Recognition of multiple endotypes that suggest alternative therapies for less severe cases.
  • Effective pharmacotherapies have been developed targeting specific non-anatomical endotypes.

Cite This Study

McNicholas et al. (2026) studied this question.

synapsesocial.com/papers/69c4cddcfdc3bde44891ab21https://doi.org/10.1002/resp.70233
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Precision Pharmacotherapy for Obstructive Sleep Apnea: Matching Targeted Drugs to Patient Endophenotypes2026
  2. 20673 Pharmacologic Modulation of Obstructive Sleep Apnea: A Systematic Analysis of Endotype Directed Therapies2026
  3. 3Redefining Obstructive Sleep Apnea: Treatment in the Modern Era2026 · 1 citations
  4. 4Obstructive sleep apnea pharmacology2026
  5. 5Current Updates on Pharmacotherapy for Obstructive Sleep Apnea2026