PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 27, 2026Scientific Reports0 citationsOpen Access

Combined Exercise and Dietary Interventions Improve Liver Health in Obese Mice

Exercise and time-restricted and/or dietary feeding jointly improve hepatic lipid homeostasis in diet-induced obese mice

View Full Paper
Ask AI
Bookmark
Share

Authors

NGNicole Power GuerraABAnja U. BräuerMGMarkus H. Gräler

Discussion

Loading...

Member takes

Overview

Research shows that combined exercise and diet improve liver function in obese mice, suggesting effective strategies for metabolic health.

Key Points

  • This research aims to explore the individual and combined effects of exercise, low-fat diet, and time-restricted feeding on liver health in obese mice.
  • Examined effects of low-fat diet (LFD), treadmill (TM) exercise, and time-restricted feeding (TRF) in diet-induced obese mice.
  • Analyzed comprehensive hepatic lipid composition and related gene expression.
  • Compared individual vs. combined intervention effects on liver function.
  • LFD led to the greatest weight loss and normalized key liver enzyme levels (AST, ALT).
  • Combined TM and TRF reduced liver damage markers under high-fat diet (HFD) conditions.
  • LFD with TRF and/or TM decreased lipogenic gene expression, while certain genes were upregulated in combined groups.
  • Lipidomics revealed increased sphingomyelin and phosphatidylcholine levels with LFD interventions.

Cite This Study

Guerra et al. (2026) studied this question.

synapsesocial.com/papers/69c61ff615a0a509bde18520https://doi.org/10.1038/s41598-026-45394-4
View Full Paper
Ask AI
Bookmark
Share