This development features a multifunctional hydrogel that enhances ESD efficiency and provides postoperative support, indicating a novel approach for gastrointestinal therapy.
Key Points
To create a multifunctional hydrogel that addresses limitations in endoscopic submucosal dissection (ESD) procedures.
Developed a hydrogel via Schiff base reactions between carboxymethyl chitosan and oxidized dextran.
Incorporated methylene blue for visualization during ESD.
Integrated mesoporous silica nanoparticles loaded with Bupivacaine for sustained release of analgesia.
Evaluated hydrogel's properties such as injectability, self-healing capacity, and tissue adhesion in physiological conditions.
Hydrogel provides sustained local analgesia for over 48 hours post-ESD.
Exhibits excellent tissue adhesion and wound protection capabilities.
Demonstrates potent antibacterial and antioxidant activities in vitro and in vivo.
Shows favorable biocompatibility and tolerability during comprehensive safety evaluations.