PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
March 27, 2026Open Access

Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor

View Full Paper
Ask AI
Bookmark
Share

Authors

CHChristopher HunterMMMaria Cristina Misuraca

Discussion

Loading...

Member takes

Overview

Demonstrates negative cooperativity in H-bond formation with an oxygen acceptor, indicating complex interactions.

Key Points

  • To quantify the negative cooperativity effects in H-bond networks involving phosphoryl oxygen and two H-bond donors.
  • Preparation of compounds with intramolecular H-bonds between phosphinamide and phenol
  • Measurement of association constants using titrations
  • Confirmation of interactions via NMR spectroscopy in n-octane solution
  • Electron-withdrawing substituents decrease intermolecular H-bond strength
  • Determination of cooperativity parameter κ = -0.82
  • Establishment of a linear relationship between H-bond parameters α and β.

Cite This Study

Hunter et al. (2026) studied this question.

synapsesocial.com/papers/69c620d515a0a509bde197e6https://doi.org/10.17863/cam.128668
View Full Paper
Ask AI
Bookmark
Share